Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
نویسندگان
چکیده
منابع مشابه
Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity.
Although the apoptotic role of caspases has been largely understood, accumulating evidence in Drosophila suggests that caspases also control other processes than apoptotic cell death. However, how caspases contribute to the development of the mammalian nervous system remains obscure. Here, we provide unique evidence that Apaf-1/caspase-9-mediated caspase signaling regulates the development of o...
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Recombinant WT and mutant caspase-9 proteins (20 nM) were incubated in the presence or absence of recombinant Apaf-1 (20 nM) in buffer A. The reaction mixtures were stimulated with cytochrome c (5 ng ml) and dATP (1 mM) and incubated for 0±60 min at 30 8C with puri®ed procaspase-3 C163A, and the processing of procaspase-3 was analysed by western blot analysis with anti-caspase-3 antibody (Fig. ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0910488107